our simulator leverages cutting-edge bioengineering

modular chambers simulate the gastrointestinal lumen and ovarian microenvironment, with embedded sensors for continuous monitoring of key analytes such as short-chain fatty acids (SCFAs), bile acids, and steroid hormones via liquid chromatography-mass spectrometry (LC-MS) interfaces

research shows that the gut microbiome influences up to 70-80% of circulating estrogens via β-glucuronidase and β-glucosidase enzymes produced by bacteria like Escherichia coli, Bifidobacterium, and Clostridium species

dysbiosis here disrupts hormone homeostasis, exacerbating PCOS (characterized by hyperandrogenism and insulin resistance), endometriosis (with elevated estrone/estradiol ratios), and fertility issues (altered follicular development) Yet, as noted in recent meta-analyses, over 90% of reproductive research ignores these microbial contributions, relying on animal models or single-organ cultures that overlook real-time feedback loops

current in-vitro → in-vivo translation failure rate > 95 % for PCOS / endometriosis drugs

aurasyn democratizes access to sophisticated modeling, enabling researchers to

test hypotheses on microbial-hormone causality without ethical constraints of in vivo studies

integrate patient-specific data for precision medicine, such as fecal microbiomes from PCOS patients showing reduced alpha diversity (Shannon Index <3.5) and enriched Firmicutes/Bacteroidetes ratios

foster global collaborations by providing scalable, cost-effective tools that reduce reliance on expensive clinical trials